Christian Doppler Laboratory for Innovative Therapy Approaches in Sepsis

Module 1

To develop dynamic cell culture models for sepsis.
To apply these models to gain new knowledge on the pathophysiology of sepsis and on potential novel targets for sepsis therapy (platelets, extracellular histones, microvesicles).
To apply these models in pre-clinical development to evaluate the efficacy of supportive extracorporeal blood purification approaches for sepsis.
To assess the role of microvesicles as both markers and targets for therapy in sepsis.
To develop methods for the removal of extracellular histones and microvesicles using extracorporeal blood purification.
To develop and apply cell culture models to test and improve the biocompatibility of existing blood purification therapies.
To provide tools supporting the approval of medical devices according to ISO 10993, minimizing the need for animal experiments during the approval process.