Logo Christian Doppler Institut

Christian Doppler Laboratory for
Innovative Therapy Approaches in Sepsis

Meduni Wien Fresenius Medical Care Logo Donau Uni Krems

Pathophysiology

The clinical manifestations of sepsis are not caused directly by the invading microbes (gram-negative or gram-positive bacteria, fungi, parasites, or viruses), but the systemic reaction is a result of dysregulation of the patient´s own inflammatory response. Hyper-activation of cellular innate immune responses is associated with excessive inflammatory reactions, and activation of the complement system and malfunction of regulatory mechanisms lead to loss of control of inflammation during sepsis. When the initial, hyper-inflammatory phase of sepsis is passed, patients succumb at later time points with a prolonged immunosuppressive state. Immune cells can undergo ‘immune paralysis’ caused by a complete shut-down of essential intracellular signaling pathways leading to dysfunction of the adaptive immune system