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Christian Doppler Laboratory for
Innovative Therapy Approaches in Sepsis

Meduni Wien Fresenius Medical Care Logo Donau Uni Krems



Peer-reviewed articles:


     Eichhorn T, Linsberger I, Lauková L, Tripisciano C, Fendl B, Weiss R, König F, Valicek G, Miestinger G, Hörmann C, Weber V

     Analysis of inflammatory mediator profiles in sepsis patients reveals that extracellular histones are strongly elevated in non-survivors.

     Med Inflamm 2020, submitted    


     Fendl B, Weiss R, Eichhorn T, Linsberger I, Afonyushkin T, Puhm F, Binder CJ, Fischer MB, Weber V

     Extracellular vesicles are associated with C-reactive protein in sepsis and elicit a pro-inflammatory response in human monocytes.

     Sci Rep 2020, submitted


     Lauková L, Weiss R, Semak V, Weber V

     Desialylation of platelet surface glycans enhances platelet adhesion to adsorbent polymers in whole blood lipoprotein apheresis.

     Transfus Apher Sci 2020, submitted


     Huber S, Weinberger J, Pilecky M, Lorenz IH, Schildberger A, Weber V, Fuchs S, Posch W, Knabl L, Würzner R, Posch A

     A high leukocyte count and administration of hydrocortisone hamper PCR-based diagnostics for bloodstream infections.

     Diagn Microbiol Infect Dis 2020, submitted


      Lauková L, Konečná B, Janovičová L, Vlková B, Celec P

     Deoxyribonucleases and their applications in biomedicine.

     Biomolecules 2020, 10:1036


     Tripisciano C, Weiss R, Karuthedom George S, Fischer MB, Weber V

     Extracellular vesicles derived from platelets, red blood cells, and monocyte-like cells differ regarding their ability to induce factor XII-dependent

     thrombin generation.

     Front Cell Dev Biol 2020, 8:298


     Wisgrill L, Lamm C, Hell L, Thaler J, Berger A, Weiss R, Weber V, Rinoesl H, Hiesmayr MJ, Spittler A, Bernardi M

     Influence of hemoadsorption during cardiopulmonary bypass on blood vesicle count and function.

     J Transl Med 2020, 18(1):202


     Weiss VU, Balantic K, Pittenauer E, Tripisciano C, Friedbacher G, Weber V, Marchetti-Deschmann M, Allmaier G

     Nano electrospray differential mobility analysis based sizeselection of liposomes and very-low density lipoprotein particles for offline hyphenation

     to MALDI mass spectrometry.

     J Pharm Biomed Anal 2020, 179:112998


     Pasztorek M, Rossmanith E, Mayr C, Hauser F, Jacak J, Ebner A, Weber V, Fischer MB

     Influence of platelet lysate on 2D and 3D amniotic mesenchymal stem cell cultures.

     Front Bioeng Biotechnol 2019, 7:338


     Almeria C, Weiss R, Roy M, Tripisciano C, Kasper C, Weber V, Egger D

     Hypoxia conditioned mesenchymal stem cell-derived extracellular vesicles induce increased vascular tube formation in vitro.

     Front Bioeng Biotechnol 2019, 7:292


     Fendl B, Weiss R, Eichhorn T, Spittler A, Fischer MB, Weber V

     Storage of human whole blood, but not isolated monocytes, preserves the distribution of monocyte subsets.

     Biochem Biophys Res Commun 2019, 517(4):709-714    


     Pilecky M, Schildberger A, Knabl L, Orth-Höller D, Weber V

     Influence of antibiotic treatment on the detection of S. aureus in whole blood following pathogen enrichment.

     BMC Microbiol 2019, 19(1):180


     Puhm F, Afonyushkin T, Resch U, Obermayer G, Rohde M, Penz T, Schuster M, Wagner G, Rendeiro AF, Melki I, Kaun C, Wojta J, Bock C, Jilma B,

     Mackman N, Boilard E, Binder CJ

     Mitochondria are a subset of extracellular vesicles released by activated monocytes and induce type I IFN and TNF responses in endothelial cells.

     Circ Res 2019, 125(1):43-52


     Pilecky M, Schildberger A, Orth-Höller D, Weber V

     Pathogen enrichment from whole blood for diagnostic and therapeutic applications: Prospects and limitations.

     Diagn Microbiol Infect Dis 2019, 94(1):7-14


     Lauková L, Bertolo EMJ, Zelinková M, Borbélyová V, Čonka J, Kovalčíková AG, Domonkos E, Vlková B, Celec P

     Early dynamics of plasma DNA in a mouse model of sepsis.

     Shock 2019, 52(2): 257-263


     Fendl B, Eichhorn T, Weiss R, Tripisciano C, Spittler A, Fischer MB, Weber V

     Differential interaction of platelet-derived extracellular vesicles with circulating immune cells: roles of TAM receptors, CD11b, and phosphatidylserine.

     Front Immunol 2018, 9:2797


     Théry C, Witwer KW, ..., Weber V, et al.

     Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and

     update of the MISEV2014 guidelines.

     J Extracell Vesicles 2018, 7:1, Article ID 1535750


     Egger D, Tripisciano C, Weber V, Dominici M, Kasper C

     Dynamic cultivation of mesenchymal stem cell aggregates.

     Bioengineering 2018, 5, 48


     Gubensek J, Strobl K, Harm S, Weiss R, Eichhorn T, Buturovic-Ponikvar J, Weber V, Hartmann J

     Influence of citrate concentration on the activation of blood cells in an in vitro dialysis setup.

     PLoS ONE 2018, 13(6):e0199204


     Weiss R, Gröger M, Rauscher S, Fendl B, Eichhorn T, Fischer MB, Spittler A, Weber V

     Differential interaction of platelet-derived extracellular vesicles with leukocyte subsets in human whole blood.

     Sci Rep 2018, 8(1):6598


     Mushahary D, Spittler A, Kasper C, Weber V, Charwart V

     Isolation, cultivation, and characterization of human mesenchymal stem cells.

     Cytometry A 2018, 93(1):19-31   


     Eichhorn T, Hartmann J, Harm S, Linsberger I, König F, Valicek G, Miestinger G, Hörmann C, Weber V

     Clearance of selected cytokines with continuous veno-venous hemodialysis using Ultraflux EMiC2 versus Ultraflux AV1000S.

     Blood Purif 2017, 44:260-266


     Tripisciano C, Weiss R, Eichhorn T, Spittler A, Heuser T, Fischer MB, Weber V

     Different potential of extracellular vesicles to support thrombin generation: Contributions of phosphatidylserine, tissue factor, and cellular origin.

     Sci Rep 2017, 7(1):6522


     Weiss R, Eichhorn T, Spittler A, Micusik M, Fischer MB, Weber V

      Release and cellular origin of extracellular vesicles during circulation of whole blood over adsorbent polymers for lipid apheresis.

      J Biomed Mater Res B 2017, 105(3):636-646


     Weber V, Groth T

     Materials, surfaces, and systems for extracorporeal therapies and beyond.

     Int J Artif Organs 2017, 40(1):1-3


     Eichhorn T, Fischer MB, Weber V

     Mechanisms of endothelial activation in sepsis and cell culture models to study the heterogeneous host response.

     Int J Artif Organs 2017, 40(1):9-14


     Semak V, Fischer MB, Weber V

     Biomimetic principles to develop blood compatible surfaces.

     Int J Artif Organs 2017, 40(1):22-30


     Strobl K, Harm S, Weber V, Hartmann J

     The role of ionized calcium and magnesium in regional citrate anticoagulation and its impact on inflammatory parameters.

     Int J Artif Organs 2017, 40(1):15-21


     Weiss R, Fischer MB, Weber V
The impact of citrate concentration on adhesion of platelets and leukocytes to adsorbents in whole blood lipid apheresis.
      J Clin Apher 2017, 32(6):375-383   


      Eichhorn T, Rauscher S, Hammer C, Gröger M, Fischer MB, Weber V

      Polystyrene-divinylbenzene based adsorbents reduce endothelial activation and monocyte adhesion under septic conditions in a pore-size dependent manner.

      Inflammation 2016, 39(5):1737-1746


      Fendl B, Weiss R, Fischer MB, Spittler A, Weber V

      Characterization of extracellular vesicles in whole blood: Influence of pre-analytical parameters and visualization of vesicle-cell interactions using imaging

      flow cytometry.

      Biochem Biophys Res Commun 2016, 478(1):168-173


      Buchacher T, Ohradanova-Repic A, Fischer MB, Weber V

      M2 polarization of human macrophages favors survival of the intracellular pathogen Chlamydia pneumoniae.

      PLoS ONE 2015, 10(11):e0143593


      Tsiantoulas D, Perkmann T, Afonyushkin T, Mangold, A, Prohaska TA; Papac-Milicevic N, Millischer V, Bartel C,
      Hörkkö S, Boulanger CM, Tsmikias S, Fischer MB, Witztum JL, Lang IM, Binder CJ

      Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies.
       J Lipid Res 2015, 56:440-448


      Buchacher T, Wiesinger-Mayr H, Vierlinger K, Rüger BM, Stanek G, Fischer MB, Weber V
      Human blood monocytes support persistence, but not replication of the intracellular pathogen C. pneumoniae.
      BMC Immunol 2014, 15:60


     Tripisciano C, Eichhorn T, Harm S, Weber V
      Adsorption of the inflammatory mediator high-mobility group box 1 by polymers with different charge and porosity.
      Biomed Res Int 2014, Article ID 238160


     Weiss R, Spittler A, Schmitz G, Fischer MB, Weber V
     Thrombocyte adhesion and release of extracellular microvesicles correlate with surface roughness of adsorbent polymers for lipid apheresis.
     Biomacromolecules 2014, 15(7):2648-2655


     La Spina R, Tripisciano C, Mecca T, Cunsolo F, Weber V, Mattiasson B

     Chemically modified poly(2-hydroxyethyl methacrylate) cryogel for the adsorption of heparin.

     J Biomed Mater Res B Appl Biomater 2014, 102(6):1207-1216


     Schildberger A, Rossmanith E, Eichhorn T, Strassl K, Weber V

     Monocytes, peripheral blood mononuclear cells, and THP-1 cells exhibit different cytokine expression patterns following stimulation with lipopolysaccharide.

     Mediators Inflamm 2013, Volume 2013, Article ID 697972


     Weber V, Tripisciano C
     Application potential of cellulose-based adsorbents in extracorporeal blood purification.
     Trends Carbohydrate Res 2013; 5(2):1-6

Presentations at conferences:

      Tripisciano C, Weiss R, Fendl B, Eichhorn T, Fischer MB, Spittler A, Weber V
      Characterization and biological activity of extracellular vesicles.

      Extracellular Vesicle Seminar, Vienna, Austria, 13-14 February, 2017 (talk)


      Fendl B, Weiss R, Weber V
      Influence of anticoagulation on microvesicle release in stored whole blood.
      International Society for Extracellular Vesicles (ISEV) 2016, Rotterdam, The Netherlands, 4-7 May, 2016 (poster)


      Tripisciano C, Weiss R, Eichhorn T, Weber V
      Pro-coagulant activity of platelet-derived extracellular vesicles.
      International Society for Extracellular Vesicles (ISEV) 2016, Rotterdam, The Netherlands, 4-7 May, 2016 (poster and talk)


      Tripisciano C
      Pro-coagulant potential of microvesicles.
      Cell Culture Days, Graz, Austria, 28-29 April, 2016 (talk)


      Eichhorn T
      Cell-culture models to study endothelial activation.
      Cell Culture Days, Graz, Austria, 28-29 April, 2016 (talk)


      Weiss R, Fischer MB, Weber V
      Citrate concentration influences platelet activation and microvesicle generation during lipid apheresis.
      7th International BioNanoMed 2016 Congress, Krems, Austria, 6-8 April, 2016 (poster)


      Weber V
      Cell culture models to monitor endothelial activation.
      13th International Life Science Meeting, Krems, Austria, 6-8 April, 2016 (invited lecture)


      Weber V, Hartmann J, Fischer MB
      Perspectives in extracorporeal therapies.
      ESAO Symposium dedicated to Dieter Falkenhagen, Krems, Austria, 5 April, 2016 (talk)


      Eichhorn T, Rauscher S, Hammer C, Gröger M, Fischer MB, Weber V
      A flow model to study endothelial activation induced by lipopolysaccharide or septic plasma and to monitor the effect of cytokine adsorption.
      Joint Meeting on Vascular Biology, Inflammation and Thrombosis, Vienna, Austria, 31 March - 1 April, 2016 (talk)


      Weber V, Hartmann J., Harm S, Linsberger I, Eichhorn T, Valicek G, Miestinger G, Hörmann C
      Enhanced clearance of interleukin-6 with continuous veno-venous haemodialysis using Ultraflux EMiC2 vs. Ultraflux AV1000S.
      36th International Symposium on Intensive Care and Emergency Medicine (ISICEM), Brussels, Belgium, 15-18 March, 2016 (poster)

      Critical Care, Vol. 20, S2:80, 2016